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Secosteroidal hydrazides: Promising scaffolds for anti-breast cancer agents Научная публикация

Журнал The Journal of Steroid Biochemistry and Molecular Biology
ISSN: 1879-1220 , E-ISSN: 0960-0760
Вых. Данные Год: 2021, Том: 214, Номер статьи : 106000, Страниц : DOI: 10.1016/j.jsbmb.2021.106000
Авторы Ilovaisky Alexey I. 1 , Merkulova Valentina M. 1 , Chernoburova Elena I. 1 , Shchetinina Marina A. 1 , Salnikova Diana I. 2 , Scherbakov Alexander M. 2 , Zavarzin Igor V. 1 , Terent’ev Alexander O. 1
Организации
1 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russia
2 Department of Experimental Tumor Biology, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 24 Kashirskoye sh., Moscow, 115522, Russia

Реферат: A convenient and selective approach to 13,17-secoestra-1,3,5(10)-trien-17-oic acid hydrazides and their N’-(het)arylmethylene derivatives was disclosed and these novel types of secosteroids were screened for cytotoxicity against hormone-dependent human breast cancer cell line MCF-7. A number of 13,17-secoestra-1,3,5(10)-trien-17-oic acid [N’-(het)arylmethylene]hydrazides show significant cytotoxic effect comparable or superior to that for reference drug cisplatin. Compound 3l exhibits the highest activity with the IC50 value of about 2 μM and is 2.8 times more active than cisplatin. Hit 13,17-secoestra-1,3,5(10)-trien-17-oic acid [N’-(het)arylmethylene]hydrazides 3d, 3l and 3q are characterized by high cytotoxicity and good selectivity towards MCF-7 breast cancer cells. The synthesized secosteroids may be considered as new promising antitumor agents.
Библиографическая ссылка: Ilovaisky A.I. , Merkulova V.M. , Chernoburova E.I. , Shchetinina M.A. , Salnikova D.I. , Scherbakov A.M. , Zavarzin I.V. , Terent’ev A.O.
Secosteroidal hydrazides: Promising scaffolds for anti-breast cancer agents
The Journal of Steroid Biochemistry and Molecular Biology. 2021. V.214. 106000 . DOI: 10.1016/j.jsbmb.2021.106000 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: WOS:000701839300003
Scopus: 2-s2.0-85115365104
OpenAlex: W3201600383
Цитирование в БД:
БД Цитирований
OpenAlex 8
Scopus 8
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