Dimethyl 2-(2,4-Diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonate

Dimethyl 2-(2,4-Diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonate Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2021, Volume: 2022, Number: 1, Article number : M1308, Pages count : DOI: 10.3390/m1308

Authors

Ryzhkova Yuliya E. ¹ , Maslov Oleg I. ¹ , Elinson Michail N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

Dimethyl sulfoxide (DMSO) is widely used as a solvent in organic synthesis and in pharmacology because of its low cost, stability, and non-toxicity. Multicomponent reactions are a powerful synthetic tool for the rapid and efficient construction of complicated molecular frameworks. In this communication, the multicomponent transformation of salicylaldehyde, malononitrile dimer, and dimethyl malonate in DMSO at room temperature was carefully investigated to give dimethyl 2-(2,4-diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonate with good yield. The structure of the new compound was established by means of elemental analysis and mass, nuclear magnetic resonance, and infrared spectroscopy.

Ryzhkova Y.E. , Maslov O.I. , Elinson M.N.
Dimethyl 2-(2,4-Diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonate
Molbank. 2021. V.2022. N1. M1308 . DOI: 10.3390/m1308 WOS Scopus OpenAlex

≡ Web of science:	WOS:000774086500001
≡ Scopus:	2-s2.0-85123096128
≡ OpenAlex:	W4200373643