Synthesis and Biological Evaluation of New 4,5,6,7‐Tetrahydro‐1H‐imidazo[4,5‐c]pyridine Derivatives

Synthesis and Biological Evaluation of New 4,5,6,7‐Tetrahydro‐1H‐imidazo[4,5‐c]pyridine Derivatives Full article

Journal

ChemistrySelect
ISSN: 2365-6549

Output data

Year: 2020, Volume: 5, Number: 44, Pages: 14017-14020 Pages count : 4 DOI: 10.1002/slct.202003440

Authors

Prezent Mikhail A. ¹ , Baranin Sergey V. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation

A number of new spinaceamine derivatives have been synthesized by the Suzuki reaction of 5-Boc-2-iodo-spinaciamine with aryl or heteryl boronic acids. The obtained compounds exhibited a varying degree of ABTS radical-scavenging activity, and some of them found to be more effective radical-scavengers comparing with spinacine. Both spinacine and its synthesized derivatives do not inhibit cholinesterases and carboxylesterase.

Prezent M.A. , Baranin S.V.
Synthesis and Biological Evaluation of New 4,5,6,7‐Tetrahydro‐1H‐imidazo[4,5‐c]pyridine Derivatives
ChemistrySelect. 2020. V.5. N44. P.14017-14020. DOI: 10.1002/slct.202003440 WOS Scopus OpenAlex

≡ Web of science:	WOS:000594505700031
≡ Scopus:	2-s2.0-85096910780
≡ OpenAlex:	W3108184712