New synthetic corticosteroids inhibit Epstein–Barr virus release

New synthetic corticosteroids inhibit Epstein–Barr virus release Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2021, Volume: 31, Number: 5, Pages: 667-669 Pages count : 3 DOI: 10.1016/j.mencom.2021.09.025

Authors

Malykh Andrei G. ¹ , Pavlov Andrey R. ¹ , Komkov Alexander V. ² , Volkova Yulia A. ² , Menchikov Leonid G. ² , Zavarzin Igor V. ²

Affiliations

1	Capital Biosciences, Inc., MD 20878, USA
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Novel spiroandrostene-17,6'-[1,3,4]thiadiazines obtained by synthesis from 16β,17β-epoxy-17-isopregn-5-en-3β-ol-20-one and N-aryl-2-hydrazino-2-thioxoacetamide efficiently inhibited the release of Epstein–Barr virus from cells carrying the virus in culture. Other studied steroids, such as Spirolactone, Digitonin, Diosgenin, and Hecogenin were inactive. DMSO alone was found to inhibit the virus release, as well, likely, because of changing properties of the cell membranes. The novel steroids, Spironolactone and most analogues display no or low cell toxicity while Digitonin produced a significant toxic effect.

Malykh A.G. , Pavlov A.R. , Komkov A.V. , Volkova Y.A. , Menchikov L.G. , Zavarzin I.V.
New synthetic corticosteroids inhibit Epstein–Barr virus release
Mendeleev Communications. 2021. V.31. N5. P.667-669. DOI: 10.1016/j.mencom.2021.09.025 WOS Scopus OpenAlex

≡ Web of science:	WOS:000717972600025
≡ Scopus:	2-s2.0-85119483419
≡ OpenAlex:	W3210706385