Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury

Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury Научная публикация

Журнал

JACC: Basic to Translational Science
ISSN: 2452-302X

Вых. Данные

Год: 2022, Том: 7, Номер: 11, Страницы: 1102-1116 Страниц : 15 DOI: 10.1016/j.jacbts.2022.05.004

Авторы

Kim Hyoung Kyu ^1,2 , Kim Min ^1,3 , Marquez Jubert C. ^1,2 , Jeong Seung Hun ^1,2 , Ko Tae Hee ^1,2 , Noh Yeon Hee ^1,2 , Kha Pham Trong ^1,2 , Choi Ha Min ^1,2 , Kim Dong Hyun ⁴ , Kim Jong Tae ⁵ , Yang Young Il ⁵ , Ko Kyung Soo ^1,2 , Rhee Byoung Doo ^1,2 , Shubina Larisa K. ⁶ , Makarieva Tatyana N. ⁶ , Yashunsky Dmitry Y. ⁷ , Gerbst Alexey G. ⁷ , Nifantiev Nikolay E. ⁷ , Stonik Valentin A. ⁶ , Han Jin ^1,2,3

Организации

1	Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea
2	Department of Health Sciences and Technology, Graduate School, Inje University, Busan, South Korea
3	Department of Physiology, BK Plus Project Team, College of Medicine, Inje University, Busan, South Korea
4	Department of Pharmacology and Pharmaco-Genomics Research Center, College of Medicine, Inje University, Busan, South Korea
5	Paik Institute for Clinical Research, Inje University College of Medicine, Busan, South Korea
6	G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok, Russia
7	Laboratory of Glycoconjugate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Recent trends suggest novel natural compounds as promising treatments for cardiovascular disease. The authors examined how neopetroside A, a natural pyridine nucleoside containing an α-glycoside bond, regulates mitochondrial metabolism and heart function and investigated its cardioprotective role against ischemia/reperfusion injury. Neopetroside A treatment maintained cardiac hemodynamic status and mitochondrial respiration capacity and significantly prevented cardiac fibrosis in murine models. These effects can be attributed to preserved cellular and mitochondrial function caused by the inhibition of glycogen synthase kinase-3 beta, which regulates the ratio of nicotinamide adenine dinucleotide to nicotinamide adenine dinucleotide, reduced, through activation of the nuclear factor erythroid 2–related factor 2/NAD(P)H quinone oxidoreductase 1 axis in a phosphorylation-independent manner.

Kim H.K. , Kim M. , Marquez J.C. , Jeong S.H. , Ko T.H. , Noh Y.H. , Kha P.T. , Choi H.M. , Kim D.H. , Kim J.T. , Yang Y.I. , Ko K.S. , Rhee B.D. , Shubina L.K. , Makarieva T.N. , Yashunsky D.Y. , Gerbst A.G. , Nifantiev N.E. , Stonik V.A. , Han J.
Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury
JACC: Basic to Translational Science. 2022. V.7. N11. P.1102-1116. DOI: 10.1016/j.jacbts.2022.05.004 WOS Scopus OpenAlex

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