3-(4-Bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxazol-5(2H)-one

3-(4-Bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxazol-5(2H)-one Научная публикация

Журнал

Molbank
ISSN: 1422-8599

Вых. Данные

Год: 2020, Том: 2020, Номер: 2, Номер статьи : M1135, Страниц : DOI: 10.3390/m1135

Авторы

Ryzhkova Yuliya E. ¹ , Ryzhkov Fedor V. ¹ , Elinson Michail N. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

In this communication, the electrochemically induced multicomponent transformation of 3-methylbenzaldehyde, 3-(4-bromophenyl)isoxazol-5(4H)-one and kojic acid in n-PrOH in an undivided cell in the presence of sodium bromide was carefully investigated to give 3-(4-bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxa- zol-5(2H)-one in good yield. The structure of the new compound was established by means of elemental analysis, mass-, nuclear magnetic resonance and infrared spectroscopy. Furthermore, its structure was determined and confirmed by X-ray analysis. The synthesized compound is a promising compound for different biomedical applications, and, in particular, for the regulation of inflammatory diseases, as shown by docking studies in this research.

Ryzhkova Y.E. , Ryzhkov F.V. , Elinson M.N.
3-(4-Bromophenyl)-4-{[3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl](m-tolyl)methyl}isoxazol-5(2H)-one
Molbank. 2020. V.2020. N2. M1135 . DOI: 10.3390/m1135 WOS Scopus OpenAlex

≡ Web of science:	WOS:000551575100012
≡ Scopus:	2-s2.0-85085128515
≡ OpenAlex:	W3025222744