A simple synthesis of 2-{2-[(arylmethylidene)amino]-indazol-3-yl}malonate esters

A simple synthesis of 2-{2-[(arylmethylidene)amino]-indazol-3-yl}malonate esters Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2020, Volume: 56, Number: 5, Pages: 555-561 Pages count : 7 DOI: 10.1007/s10593-020-02699-0

Authors

Kuznetsova Lyubov I. ¹ , Chagarovskiy Alexey O. ^2,1 , Levina Irina I. ³ , Rybakov Victor B. ⁴ , Ivanova Olga A. ^4,1 , Trushkov Igor V. ^2,1

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia
3	M. N. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
4	Lomonosov Moscow State University, Moscow, Russia

A method was developed for the synthesis of dimethyl {2-[(arylmethylidene)amino]-2H-indazol-3-yl}malonates on the basis of a Knoevenagel condensation between 2-azidobenzaldehyde and dimethyl malonate, followed by treatment of the obtained adduct with aromatic aldehydes in the presence of polymer-supported triphenylphosphine. It was shown that the interaction of the synthesized Schiff bases with Corey ylide provided a route for the synthesis of 2-(aziridin-1-yl)indazoles.

Kuznetsova L.I. , Chagarovskiy A.O. , Levina I.I. , Rybakov V.B. , Ivanova O.A. , Trushkov I.V.
A simple synthesis of 2-{2-[(arylmethylidene)amino]-indazol-3-yl}malonate esters
Chemistry of Heterocyclic Compounds. 2020. V.56. N5. P.555-561. DOI: 10.1007/s10593-020-02699-0 WOS Scopus OpenAlex

Web of science:	WOS:000537354000002
Scopus:	2-s2.0-85085912921
OpenAlex:	W3034168234

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OpenAlex	3
Scopus	1
Web of science	1