Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome

Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome Научная публикация

Журнал

Russian Journal of Bioorganic Chemistry
ISSN: 1608-330X , E-ISSN: 1573-9163

Вых. Данные

Год: 2022, Том: 48, Номер: 6, Страницы: 1109-1122 Страниц : 14 DOI: 10.1134/s1068162022060152

Авторы

Kiselevskiy M.V. ¹ , Anisimova N.Yu. ¹ , Bilan M.I. ² , Usov A.I. ² , Ustyuzhanina N.E. ² , Petkevich A.A. ¹ , Shubina I.Zh. ¹ , Morozevich G.E. ³ , Nifantiev N.E. ²

Организации

1	Blokhin National Medical Research Center of Oncology, Moscow, 115552 Russia
2	Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russia
3	Orekhovich Institute of Biomedical Chemistry, Moscow, 119121 Russia

Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia and multiple organ failure. The clinical picture of COVID-19 is heterogeneous and involves most physiological systems; therefore, drugs with a wide spectrum of mechanism of action are required. The choice of the treatment strategy for post-COVID-19 syndrome is still a challenge to be resolved. Polysaccharides with a high fucose content derived from seaweed and marine animals can form the basis for the subsequent development of promising agents for the treatment of COVID-19 and post-COVID-19 syndrome. This class of biopolymers is characterized by a variety of biological activities, including antiviral, antithrombotic, anticoagulant, hemo-stimulating, anti-inflammatory and immune-regulatory. Low molecular weight derivatives of these polysaccharides, as well as synthetic oligosaccharides with a sufficient amount and sulfation type may be considered as the most promising compounds due to their better bioavailability, which undoubtedly increases their therapeutic potential.

Kiselevskiy M.V. , Anisimova N.Y. , Bilan M.I. , Usov A.I. , Ustyuzhanina N.E. , Petkevich A.A. , Shubina I.Z. , Morozevich G.E. , Nifantiev N.E.
Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome
Russian Journal of Bioorganic Chemistry. 2022. V.48. N6. P.1109-1122. DOI: 10.1134/s1068162022060152 WOS Scopus OpenAlex

≡ Web of science:	WOS:000870655000014
≡ Scopus:	2-s2.0-85140247285
≡ OpenAlex:	W4306935871