Difluoromethylation of Carboxylic Acids via the Addition of Difluorinated Phosphorus Ylide to Acyl Chlorides Научная публикация
Журнал |
Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052 |
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Вых. Данные | Год: 2017, Том: 19, Номер: 19, Страницы: 5304-5307 Страниц : 4 DOI: 10.1021/acs.orglett.7b02601 | ||||
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Реферат:
A one-step protocol for the difluoromethylation of carboxylic acids is described. The reaction involves the interaction of intermediate acyl chlorides with in situ generated difluorinated phosphorus ylide Ph3P═CF2. Aromatic acids can be selectively transformed within one step either to bis-difluoromethylated alcohols or to difluorinated ketones depending on the particular reaction conditions. For bulky α-branched carboxylic acids, only ketones are produced.
Библиографическая ссылка:
Trifonov A.L.
, Levin V.V.
, Struchkova M.I.
, Dilman A.D.
Difluoromethylation of Carboxylic Acids via the Addition of Difluorinated Phosphorus Ylide to Acyl Chlorides
Organic Letters. 2017. V.19. N19. P.5304-5307. DOI: 10.1021/acs.orglett.7b02601 WOS Scopus OpenAlex
Difluoromethylation of Carboxylic Acids via the Addition of Difluorinated Phosphorus Ylide to Acyl Chlorides
Organic Letters. 2017. V.19. N19. P.5304-5307. DOI: 10.1021/acs.orglett.7b02601 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: | WOS:000412789600076 |
Scopus: | 2-s2.0-85032625868 |
OpenAlex: | W2754031959 |