Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer

Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2019, Volume: 29, Number: 5, Pages: 523-525 Pages count : 3 DOI: 10.1016/j.mencom.2019.09.015

Authors

Vereshchagin Anatoly N. ¹ , Frolov Nikita A. ¹ , Konyuhova Valeria Yu. ^2,1 , Hansford Karl A. ³ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
3	Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

Novel gemini (tail–head–spacer–head–tail) bis-quaternary ammonium compounds with a 4,4′-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogues bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in vitro activity against five bacterial strains and two fungi, with minimum inhibtory concentrations relatively independent of the counter ion.

Vereshchagin A.N. , Frolov N.A. , Konyuhova V.Y. , Hansford K.A. , Egorov M.P.
Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer
Mendeleev Communications. 2019. V.29. N5. P.523-525. DOI: 10.1016/j.mencom.2019.09.015 WOS Scopus OpenAlex

Web of science:	WOS:000496341100015
Scopus:	2-s2.0-85073723818
OpenAlex:	W2981617931

DB	Citing
OpenAlex	21
Scopus	21