A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores

A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2019, Volume: 29, Number: 2, Pages: 163-165 Pages count : 3 DOI: 10.1016/j.mencom.2019.03.015

Authors

Tsyganov Dmitry V. ¹ , Semenova Marina N. ² , Konyushkin Leonid D. ¹ , Ushkarov Vladimir I. ¹ , Raihstat Mikhail M. ¹ , Semenov Victor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation

A series of combretastatin analogues, diarylpyrazoles and diarylisoxazoles, have been synthesized and evaluated for their antimitotic tubulin-binding activity using the phenotypic sea urchin (Paracentrotus lividus) embryo assay. One pyrazole analogue and four isoxazole analogues have been identified as potent antimitotic agents comparable with combretastatins A-2 and A-4, with the lowest observable effective concentration of 1–10 nmol dm−3 for cleavage alteration of the test embryos.

Tsyganov D.V. , Semenova M.N. , Konyushkin L.D. , Ushkarov V.I. , Raihstat M.M. , Semenov V.V.
A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores
Mendeleev Communications. 2019. V.29. N2. P.163-165. DOI: 10.1016/j.mencom.2019.03.015 WOS Scopus OpenAlex

Web of science:	WOS:000467509600015
Scopus:	2-s2.0-85058076699
OpenAlex:	W2939541223

DB	Citing
OpenAlex	17
Scopus	16
Web of science	15