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Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituents Научная публикация

Журнал Journal of Natural Products
ISSN: 0163-3864 , E-ISSN: 1520-6025
Вых. Данные Год: 2019, Том: 82, Номер: 6, Страницы: 1451-1458 Страниц : 8 DOI: 10.1021/acs.jnatprod.8b00878
Авторы Samet Alexander V 1 , Shevchenko Oksana G 2 , Rusak Vyacheslav V 1 , Chartov Eduard M 1 , Myshlyavtsev Andrey B 1 , Rusanov Daniil A 1 , Semenova Marina N 3 , Semenov Victor V 1
Организации
1 N. D. Zelinsky Institute of Organic Chemistry RAS, 47 Leninsky Prospect, 119991 Moscow, Russian Federation
2 Institute of Biology of the Komi Scientific Center of the Ural Branch of RAS, 28 Kommunisticheskaya Street, 167982 Syktyvkar, Russian Federation
3 N. K. Koltzov Institute of Developmental Biology RAS, 26 Vavilov Street, 119334 Moscow, Russian Federation

Реферат: Free-radical-scavenging capacity antioxidant and membrane-protective properties of natural and related synthetic allylpolyalkoxybenzenes with different numbers of alkoxy/methoxy groups in the aromatic ring were evaluated using several in vitro models. These included the DPPH assay, inhibition of lipid peroxidation products accumulation, inhibition of H2O2-induced hemolysis, and oxidation of oxyhemoglobin. A synthetic protocol for the synthesis of natural nothoapiol (9) from a parsley seed metabolite, apiol (7), was developed. A structure–activity relationship study revealed that both the methylenedioxy fragment and methoxy groups in the aromatic ring are favorable for antioxidant activity. Hydroxyapiol (14), containing a hydroxy group in the aromatic core, was identified as the most potent compound. The pentaalkoxy-substituted nothoapiol (9) showed antioxidant activity in mouse brain homogenates, whereas in mouse erythrocytes it exhibited a marked pro-oxidant effect. Despite their low free-radical-scavenging capacity, allylpolyalkoxybenzenes can contribute to the total antioxidant potencies of plant essential oils.
Библиографическая ссылка: Samet A.V. , Shevchenko O.G. , Rusak V.V. , Chartov E.M. , Myshlyavtsev A.B. , Rusanov D.A. , Semenova M.N. , Semenov V.V.
Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituents
Journal of Natural Products. 2019. V.82. N6. P.1451-1458. DOI: 10.1021/acs.jnatprod.8b00878 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: WOS:000473827300007
Scopus: 2-s2.0-85068229719
OpenAlex: W2950580275
Цитирование в БД:
БД Цитирований
OpenAlex 41
Scopus 39
Web of science 37
Альметрики: