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Oxetane-containing metabolites: origin, structures, and biological activities Обзор

Журнал Applied Microbiology and Biotechnology
ISSN: 1432-0614 , E-ISSN: 0175-7598
Вых. Данные Год: 2019, Том: 103, Номер: 6, Страницы: 2449-2467 Страниц : 19 DOI: 10.1007/s00253-018-09576-z
Авторы Vil Vera 1 , Terent’ev Alexander O. 1 , Al Quntar Abed Al Aziz 2 , Gloriozova Tatyana A. 3 , Savidov Nick 4 , Dembitsky Valery M. 5,4,1
Организации
1 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia 119991
2 Department of Material Engineering, Faculty of Engineering, Al Quds University, Abu Dies, Palestinian Authority Jerusalem, Israel
3 Institute of Biomedical Chemistry, Moscow, Russia
4 Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, Canada
5 Biochemical Lab, National Scientific Center of Marine Biology, 17 Palchevsky Str, Vladivostok, Russia 690041

Реферат: Cyclobutanes containing one oxygen atom in a molecule are called oxetane-containing compounds (OCC). More than 600 different OCC are found in nature; they are produced by microorganisms, and also found in marine invertebrates and algae. The greatest number of them is found in plants belonging to the genus Taxus. Oxetanes are high-energy oxygen-containing non-aromatic heterocycles that are of great interest as new potential pharmacophores with a significant spectrum of biological activities. The biological activity of OCC that is produced by bacteria and Actinomycetes demonstrates antineoplastic, antiviral (arbovirus), and antifungal activity with confidence an angiogenesis stimulator, respiratory analeptic, and antiallergic activity dominate with confidence from 81 to 99%.
Библиографическая ссылка: Vil V. , Terent’ev A.O. , Al Quntar A.A.A. , Gloriozova T.A. , Savidov N. , Dembitsky V.M.
Oxetane-containing metabolites: origin, structures, and biological activities
Applied Microbiology and Biotechnology. 2019. V.103. N6. P.2449-2467. DOI: 10.1007/s00253-018-09576-z WOS Scopus OpenAlex
Идентификаторы БД:
≡ Web of science: WOS:000463023900001
≡ Scopus: 2-s2.0-85059678000
≡ OpenAlex: W2907960620
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