Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection

Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection Full article

Journal

Bioorganic & Medicinal Chemistry Letters
ISSN: 1464-3405 , E-ISSN: 0960-894X

Output data

Year: 2019, Volume: 29, Number: 14, Pages: 1765-1768 Pages count : 4 DOI: 10.1016/j.bmcl.2019.05.016

Authors

Asquith Christopher R.M. ¹ , Meili Theres ² , Laitinen Tuomo ³ , Baranovsky Ilia V. ⁴ , Konstantinova Lidia S. ^5,4 , Poso Antti ⁴ , Rakitin Oleg A. ^5,4 , Hofmann-Lehmann Regina ²

Affiliations

1	Department of Pharmacology, School of Medicine University of North Carolina at Chapel Hill, NC 27599, USA
2	Clinical Laboratory and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland
3	School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland
4	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation
5	Nanotechnology Education and Research Center, South Ural State University, Lenina Ave. 76, Chelyabinsk 454080, Russian Federation

We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.

Asquith C.R.M. , Meili T. , Laitinen T. , Baranovsky I.V. , Konstantinova L.S. , Poso A. , Rakitin O.A. , Hofmann-Lehmann R.
Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
Bioorganic & Medicinal Chemistry Letters. 2019. V.29. N14. P.1765-1768. DOI: 10.1016/j.bmcl.2019.05.016 WOS Scopus OpenAlex

Web of science:	WOS:000469785600015
Scopus:	2-s2.0-85065514855
OpenAlex:	W2944714606

DB	Citing
OpenAlex	34
Scopus	32
Web of science	28