Hydroperoxy steroids and triterpenoids derived from plant and fungi: Origin, structures and biological activities

Hydroperoxy steroids and triterpenoids derived from plant and fungi: Origin, structures and biological activities Обзор

Журнал

The Journal of Steroid Biochemistry and Molecular Biology
ISSN: 1879-1220 , E-ISSN: 0960-0760

Вых. Данные

Год: 2019, Том: 190, Страницы: 76-87 Страниц : 12 DOI: 10.1016/j.jsbmb.2019.03.020

Авторы

Vil Vera A. ¹ , Terent’ev Alexander O. ¹ , Savidov Nick ² , Gloriozova Tatyana A. ³ , Poroikov Vladimir V. ³ , Pounina Tatyana A. ⁴ , Dembitsky Valery M. ^2,1,5

Организации

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991, Moscow, Russia
2	Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South Lethbridge, AB, T1K 1L6, Canada
3	Institute of Biomedical Chemistry, 119121, Moscow, Russia
4	Far Eastern Geological Institute, Russian Academy of Sciences, 159 Prospect 100-letiya Vladivostoka, Vladivostok, 690022, Russia
5	National Scientific Center of Marine Biology, 690041, Vladivostok, Russia

Hydroperoxides (R-OOH) represent a small family of natural metabolites that have been isolated from higher plants, fungi, and marine organisms. This paper is devoted to the distribution of hydroperoxides in plants, fungi and terrestrial fungal endophytes and their biological activity. Hydroperoxides of plants demonstrate a wide range of biological activities however, antineoplastic and anti-ulcerative are most characteristic with confidence from 91 to 98 percent. For hydroperoxides from fungi, the dominant are antineoplastic and anti-hypercholesterolemic activities with confidence from 89 to 92 percent. Very interesting activity was found for some triterpenoid hydroperoxides, which is characterized as a treatment for the symptoms of dementia. The norlupane hydroperoxide shows activity for the treatment of dementia. It is interesting that the reliability of this activity was very high 97.2%. According to our preliminary data, the norlupane hydroperoxide is apparently the first natural metabolite that showed almost 100 percent activity for the treatment of dementia. However, to confirm these data requires practical and clinical experimental work.

Vil V.A. , Terent’ev A.O. , Savidov N. , Gloriozova T.A. , Poroikov V.V. , Pounina T.A. , Dembitsky V.M.
Hydroperoxy steroids and triterpenoids derived from plant and fungi: Origin, structures and biological activities
The Journal of Steroid Biochemistry and Molecular Biology. 2019. V.190. P.76-87. DOI: 10.1016/j.jsbmb.2019.03.020 WOS Scopus OpenAlex

≡ Web of science:	WOS:000471087300009
≡ Scopus:	2-s2.0-85063605767
≡ OpenAlex:	W2923490533