Synthesis, structural, spectroscopic and docking studies of new 5C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles Научная публикация
| Журнал |
Journal of Molecular Structure
ISSN: 0022-2860 , E-ISSN: 1872-8014 |
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| Вых. Данные | Год: 2017, Том: 1146, Страницы: 766-772 Страниц : 7 DOI: 10.1016/j.molstruc.2017.06.044 | ||||
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Реферат:
Multicomponent synthesis of 5-C substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles from salicylaldehydes 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 1,3-cyclohexanediones was carried out in 59–88% yields. The structures of compounds obtained were characterized by several techniques, including elemental analysis, IR, XRD, mass, 1H, 13C and NOESY spectral studies. The chromeno[2,3-b]pyridines obtained are enols in solid phase. Keto-enol equilibrium is observed in DMSO solutions. Molecular docking studies of the synthesized chromeno[2,3-b]pyridine-3-carbonitriles were also carried out to elucidate their relationship with the binding pockets of the mitogen activated protein kinase (MK). It have been found that chlorine-containing chromeno[2,3-b]pyridines have best binding energy both MK-1 and MK-2.
Библиографическая ссылка:
Vereshchagin A.N.
, Elinson M.N.
, Anisina Y.E.
, Ryzhkov F.V.
, Goloveshkin A.S.
, Novikov R.A.
, Egorov M.P.
Synthesis, structural, spectroscopic and docking studies of new 5C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles
Journal of Molecular Structure. 2017. V.1146. P.766-772. DOI: 10.1016/j.molstruc.2017.06.044 WOS Scopus OpenAlex
Synthesis, structural, spectroscopic and docking studies of new 5C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles
Journal of Molecular Structure. 2017. V.1146. P.766-772. DOI: 10.1016/j.molstruc.2017.06.044 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000406985800088 |
| Scopus: | 2-s2.0-85020939983 |
| OpenAlex: | W2627044402 |