PASE Pseudo-Four-Component Synthesis and Docking Studies of New 5-C-Substituted 2,4-Diamino-5H-Chromeno[2,3-b]pyridine-3-Carbonitriles Научная публикация
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ChemistrySelect
ISSN: 2365-6549 |
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Вых. Данные | Год: 2017, Том: 2, Номер: 17, Страницы: 4593-4597 Страниц : 5 DOI: 10.1002/slct.201700606 | ||
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Реферат:
A pot, atom and step economy (PASE) synthesis of new 5-C substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles was carried out. This process involves the one-pot, pseudo four-component reaction of salicylaldehydes, malononitrile, 1,3-cyclohexanediones and Et3N as a catalyst in acetonitrile at reflux. This novel one-pot reaction provides an effective and convenient way to 5-C cyclohexyl-functionalized chromeno[2,3-b]pyridines, which are promising compounds for different biomedical applications. The procedure utilizes readily available reagents, it is easily carried out and the work up is not complicated. 2,4-diamino-5-(2-hydroxy-6-oxocyclohex-1-en-1-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles are crystallized directly from the reaction mixture and the isolation includes only filtration. Molecular docking studies of the synthesized 2,4-diamino-5H-chromeno[2,3-b]pyridine-3-carbonitriles were also carried out to elucidate their relationship with the binding pockets of the mitogen activated protein kinase (MK).
Библиографическая ссылка:
Vereshchagin A.N.
, Elinson M.N.
, Anisina Y.E.
, Ryzhkov F.V.
, Novikov R.A.
, Egorov M.P.
PASE Pseudo-Four-Component Synthesis and Docking Studies of New 5-C-Substituted 2,4-Diamino-5H-Chromeno[2,3-b]pyridine-3-Carbonitriles
ChemistrySelect. 2017. V.2. N17. P.4593-4597. DOI: 10.1002/slct.201700606 WOS Scopus OpenAlex
PASE Pseudo-Four-Component Synthesis and Docking Studies of New 5-C-Substituted 2,4-Diamino-5H-Chromeno[2,3-b]pyridine-3-Carbonitriles
ChemistrySelect. 2017. V.2. N17. P.4593-4597. DOI: 10.1002/slct.201700606 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: | WOS:000403886100003 |
Scopus: | 2-s2.0-85040985049 |
OpenAlex: | W2626970104 |