Synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides as valuable synthons for anticancer molecules

Synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides as valuable synthons for anticancer molecules Full article

Journal

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Output data

Year: 2017, Volume: 73, Number: 48, Pages: 6728-6735 Pages count : 8 DOI: 10.1016/j.tet.2017.10.016

Authors

Chernysheva Natalia B. ¹ , Maksimenko Anna S. ¹ , Andreyanov Fedor A. ¹ , Kislyi Victor P. ¹ , Strelenko Yuri A. ¹ , Khrustalev Victor N. ^2,3 , Semenova Marina N. ⁴ , Semenov Victor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, RAS, 47 Leninsky Prospect, 119991, Moscow, Russian Federation
2	A. N. Nesmeyanov Institute of Organoelement Compounds, RAS, 28 Vavilov Street, 119991, Moscow, Russian Federation
3	Faculty of Science, RUDN University, 6 Miklukho-Maklay Street, 117198, Moscow, Russian Federation
4	N. K. Koltzov Institute of Developmental Biology, RAS, 26 Vavilov Street, 119334, Moscow, Russian Federation

The convenient regioselective scalable synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides was developed based on a condensation of simple starting materials (arylbenzaldehydes, arylnitromethanes, and ethoxycarbonylmethylpyridinium bromide) under mild conditions. The obtained synthons can be applied for the synthesis of 3,4-diarylisoxazole derivatives capable of suppressing malignant growth.

Chernysheva N.B. , Maksimenko A.S. , Andreyanov F.A. , Kislyi V.P. , Strelenko Y.A. , Khrustalev V.N. , Semenova M.N. , Semenov V.V.
Synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides as valuable synthons for anticancer molecules
Tetrahedron. 2017. V.73. N48. P.6728-6735. DOI: 10.1016/j.tet.2017.10.016 WOS Scopus OpenAlex

Web of science:	WOS:000416189200006
Scopus:	2-s2.0-85031745761
OpenAlex:	W2764249579

DB	Citing
OpenAlex	22
Scopus	22
Web of science	21