Copper-Catalyzed Coupling of Acyl Chlorides with gem-Difluorinated Organozinc Reagents via Acyl Dithiocarbamates

Copper-Catalyzed Coupling of Acyl Chlorides with gem-Difluorinated Organozinc Reagents via Acyl Dithiocarbamates Full article

Journal

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Output data

Year: 2017, Volume: 83, Number: 1, Pages: 478-483 Pages count : 6 DOI: 10.1021/acs.joc.7b02598

Authors

Ashirbaev Salavat S. ^1,2 , Levin Vitalij V. ² , Struchkova Marina I. ² , Dilman Alexander D. ²

Affiliations

1	Department of Chemistry, Moscow State University, 119991 Moscow, Leninskie Gory 1-3, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation

A cross-coupling of acyl chlorides with gem-difluorinated organozinc reagents affording difluorinated ketones is described. In the reaction, acyl chlorides are first treated with potassium dithiocarbamate to generate S-acyl dithiocarbamates, which couple with organozincs in the presence of a copper(I) catalyst.

Ashirbaev S.S. , Levin V.V. , Struchkova M.I. , Dilman A.D.
Copper-Catalyzed Coupling of Acyl Chlorides with gem-Difluorinated Organozinc Reagents via Acyl Dithiocarbamates
Journal of Organic Chemistry. 2017. V.83. N1. P.478-483. DOI: 10.1021/acs.joc.7b02598 WOS Scopus OpenAlex

Web of science:	WOS:000419749500050
Scopus:	2-s2.0-85037575782
OpenAlex:	W2770877702

DB	Citing
OpenAlex	22
Scopus	19