A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans

A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans Full article

Journal

Synthesis-Stuttgart
ISSN: 1437-210X , E-ISSN: 0039-7881

Output data

Year: 2019, Volume: 51, Number: 19, Pages: 3747-3757 Pages count : 11 DOI: 10.1055/s-0039-1690000

Authors

Makarov Anton S. ¹ , Kekhvaeva Anna E. ¹ , Chalikidi Petrakis N. ² , Abaev Vladimir T. ² , Trushkov Igor V. ^3,4 , Uchuskin Maxim G. ¹

Affiliations

1	Perm State University, Bukireva st. 15, 614990 Perm, Russian Federation
2	K. L. Khetagurov North Ossetian State University, Vatutina st. 46, 362025 Vladikavkaz, Russian Federation
3	Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela st. 1, 117997 Moscow, Russian Federatio
4	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky pr. 47, 119991 Moscow, Russian Federation

The Brönsted acid-catalyzed cascade synthesis of densely substituted benzofurans from easily available salicyl alcohols and biomass-derived furans has been developed. The disclosed sequence includes the intermediate formation of 2-(2-hydroxybenzyl)furans that quickly rearrange into functionalized benzofurans. The established protocol was applied for the total synthesis of sugikurojinol B.

Makarov A.S. , Kekhvaeva A.E. , Chalikidi P.N. , Abaev V.T. , Trushkov I.V. , Uchuskin M.G.
A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans
Synthesis-Stuttgart. 2019. V.51. N19. P.3747-3757. DOI: 10.1055/s-0039-1690000 WOS Scopus OpenAlex

Web of science:	WOS:000486191500017
Scopus:	2-s2.0-85072309309
OpenAlex:	W2953860847

DB	Citing
OpenAlex	16
Scopus	13
Web of science	11