Flexible Synthesis of Phosphoryl-Substituted Imidazolines, Tetrahydropyrimidines, and Thioamides by Sulfur-Mediated Processes

Flexible Synthesis of Phosphoryl-Substituted Imidazolines, Tetrahydropyrimidines, and Thioamides by Sulfur-Mediated Processes Научная публикация

Журнал

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Вых. Данные

Год: 2019, Том: 84, Номер: 18, Страницы: 11533-11541 Страниц : 9 DOI: 10.1021/acs.joc.9b01384

Авторы

Kozlov Mikhail ¹ , Komkov Alexander ¹ , Losev Timofey ¹ , Tyurin Alexey ¹ , Dmitrenok Andrey ¹ , Zavarzin Igor ¹ , Volkova Yulia ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation

The solvent-free sulfur-mediated reactions of phosphinic chlorides with alkyl diamines were developed for the practical synthesis of unknown phosphoryl-substituted 4,5-dihydro-1H-imidazoles, 1,4,5,6-tetrahydropyrimidines, and thioamides. Their good tolerance to functional groups, broad substrate scope, and easy scalability were shown. The chemoselective preparation of a variety of phosphoryl-substituted bis(thioamides) was accomplished via the adjustment of a solvent.

Kozlov M. , Komkov A. , Losev T. , Tyurin A. , Dmitrenok A. , Zavarzin I. , Volkova Y.
Flexible Synthesis of Phosphoryl-Substituted Imidazolines, Tetrahydropyrimidines, and Thioamides by Sulfur-Mediated Processes
Journal of Organic Chemistry. 2019. V.84. N18. P.11533-11541. DOI: 10.1021/acs.joc.9b01384 WOS Scopus OpenAlex

≡ Web of science:	WOS:000487576900015
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