One‐Pot Synthesis of 3‐(2‐Fluoroalkenyl)indoles | Sciact - научная деятельность

One‐Pot Synthesis of 3‐(2‐Fluoroalkenyl)indoles Научная публикация

Журнал

European Journal of Organic Chemistry
ISSN: 1434-193X , E-ISSN: 1099-0690

Вых. Данные

Год: 2019, Том: 2019, Номер: 27, Страницы: 4384-4396 Страниц : 13 DOI: 10.1002/ejoc.201900573

Авторы

Aldoshin Alexander S. ¹ , Tabolin Andrey A. ² , Ioffe Sema L. ² , Nenajdenko Valentine G. ¹

Организации

1	Department of Chemistry, Lomonosov Moscow State University, Leninskie gory 1, 119991 Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russian Federation

An unprecedented one-pot synthesis of 3-(fluoroalkenyl)indoles was developed. This process involves a catalyst-free Michael addition of β-fluoro-β-nitrostyrenes to indoles in neat followed by elimination of HNO2 using DBU as a base. The effectiveness of this approach was demonstrated through the preparation of variety of target products in up to 75 % isolated yield.

Aldoshin A.S. , Tabolin A.A. , Ioffe S.L. , Nenajdenko V.G.
One‐Pot Synthesis of 3‐(2‐Fluoroalkenyl)indoles
European Journal of Organic Chemistry. 2019. V.2019. N27. P.4384-4396. DOI: 10.1002/ejoc.201900573 WOS Scopus OpenAlex

≡ Web of science:	WOS:000476763500012
≡ Scopus:	2-s2.0-85068040612
≡ OpenAlex:	W2955818963