Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid

Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid Научная публикация

Журнал

Doklady Chemistry
ISSN: 1608-3113 , E-ISSN: 0012-5008

Вых. Данные

Год: 2023, Том: 513, Страницы: 367–374 Страниц : DOI: 10.1134/s0012500823700209

Авторы

Makarova E.Kh. ¹ , Ishbulatov I.V. ¹ , Makarov A.A. ¹ , Dzhemileva L.U. ² , Dzhemilev U.M. ² , D’yakonov V.A. ²

Организации

1	Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, 450075, Ufa, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

Previously unknown phenyl-substituted iodo-δ-lactone derived from 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized in 94% yield using the Ti-catalyzed intermolecular cross-cyclomagnesiation of aromatic 1,2-diene with O‑containing allene at the key stage. The in vitro cytotoxic activity of synthesized alkyl- and phenyl-substituted iodo-δ-lactones of 5Z,9Z-dienoic acids against the Jurkat, K562, U937, HL60, and Hek293 cell lines was studied, and their effect on the cell cycle and the ability to induce apoptosis were investigated using flow cytometry.

Makarova E.K. , Ishbulatov I.V. , Makarov A.A. , Dzhemileva L.U. , Dzhemilev U.M. , D’yakonov V.A.
Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid
Doklady Chemistry. 2023. V.513. P.367–374. DOI: 10.1134/s0012500823700209 WOS Scopus OpenAlex

Web of science:	WOS:001162524800004
Scopus:	2-s2.0-85183770174
OpenAlex:	W4391377610

БД	Цитирований
OpenAlex	3
Scopus	3
Web of science	3