Kharasch reaction: Cu-catalyzed and non-Kharasch metal-free peroxidation of barbituric acids

Kharasch reaction: Cu-catalyzed and non-Kharasch metal-free peroxidation of barbituric acids Full article

Journal

Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581

Output data

Year: 2019, Volume: 60, Number: 13, Pages: 920-924 Pages count : 5 DOI: 10.1016/j.tetlet.2019.02.042

Authors

Bityukov Oleg V. ¹ , Vil' Vera A. ¹ , Sazonov George K. ² , Kirillov Andrey S. ² , Lukashin Nikita V. ² , Nikishin Gennady I. ¹ , Terent'ev Alexander O. ^2,1

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya square, 125047 Moscow, Russian Federation

It was discovered that the Kharasch peroxidation of barbituric acids proceeds both with a Cu-catalyst and without a metal catalyst. Despite the presence of possible thermal-initiated side oxidation pathways, α-tert-butylperoxybarbiturates were selectively prepared from substituted barbituric acids and tert-butyl hydroperoxide.

Bityukov O.V. , Vil' V.A. , Sazonov G.K. , Kirillov A.S. , Lukashin N.V. , Nikishin G.I. , Terent'ev A.O.
Kharasch reaction: Cu-catalyzed and non-Kharasch metal-free peroxidation of barbituric acids
Tetrahedron Letters. 2019. V.60. N13. P.920-924. DOI: 10.1016/j.tetlet.2019.02.042 WOS Scopus OpenAlex

≡ Web of science:	WOS:000463127100008
≡ Scopus:	2-s2.0-85061994479
≡ OpenAlex:	W2916327891