Synthesis and properties of 1-[(adamantan-1-yl)methyl]-3-pyrazolyl ureas | Sciact

Synthesis and properties of 1-[(adamantan-1-yl)methyl]-3-pyrazolyl ureas Научная публикация

Журнал

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Вых. Данные

Год: 2019, Том: 55, Номер: 2, Страницы: 129-134 Страниц : 6 DOI: 10.1007/s10593-019-02428-2

Авторы

D’yachenko Vladimir S. ¹ , Danilov Dmitry V. ¹ , Shkineva Tatyana K. ² , Vatsadze Irina А. ² , Burmistrov Vladimir V. ¹ , Butov Gennady M. ¹

Организации

1	Volzhsky Polytechnic Institute (branch) of the Volgograd State Technical University, 42a Engelsa St., Volzhsky, 404121, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

A series of 1,3-disubstituted ureas containing 1,3,5-trisubstituted pyrazole and (adamantan-1-yl)methyl fragments were synthesized in the reaction of 1-(isocyanatomethyl)adamantane with 3- or 4-aminopyrazoles under mild conditions in 67-92% yields. The inhibitory activity of the obtained compounds with respect to human soluble epoxide hydrolase (sEH) was 16.2-50.2 nmol/l, with solubility in water of 45-85 μmol/l.

D’yachenko V.S. , Danilov D.V. , Shkineva T.K. , Vatsadze I.А. , Burmistrov V.V. , Butov G.M.
Synthesis and properties of 1-[(adamantan-1-yl)methyl]-3-pyrazolyl ureas
Chemistry of Heterocyclic Compounds. 2019. V.55. N2. P.129-134. DOI: 10.1007/s10593-019-02428-2 WOS Scopus OpenAlex

≡ Web of science:	WOS:000463779400003
≡ Scopus:	2-s2.0-85064000419
≡ OpenAlex:	W2933078262