Antioxidant Properties of Adrenaline in the Presence of Ge‐132

Antioxidant Properties of Adrenaline in the Presence of Ge‐132 Full article

Journal

European Journal of Organic Chemistry
ISSN: 1434-193X , E-ISSN: 1099-0690

Output data

Year: 2019, Volume: 2019, Number: 26, Pages: 4128-4132 Pages count : 5 DOI: 10.1002/ejoc.201900331

Authors

Filonova Galina E. ^1,2 , Nikolaevskaya Elena N. ¹ , Kansuzyan Artem V. ^1,3 , Krylova Irina V. ¹ , Egorov Mikhail P. ¹ , Jouikov Viatcheslav V. ³ , Syroeshkin Mikhail A. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 47, 119991 Moscow, Russian Federation
2	I.M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya 2, 119435 Moscow, Russian Federation
3	UMR CNRS 6226 ISCR, University of Rennes 1, 35042 Rennes, France

Using cyclic voltammetry, UV and 1H NMR spectroscopy, we have investigated the effect of 2-carboxyethylgermanium (Ge-132), the most common germanium-containing dietary supplement, on the antioxidant activity of adrenaline in aqueous solutions. The complex formed by adrenaline and Ge-132 is oxidizable at 400 mV more positive potentials compared to non-coordinated adrenaline which corresponds to its 9 kcal/mol more difficult oxidation. An equilibrium constant of the complex formation was estimated (1300 m–1). It was shown that at the concentrations <10–3 m the complex Ge-132-adrenaline is mostly dissociated to the initial compounds, and the influence of Ge-132 on the antioxidant properties of adrenaline becomes significant only when the former is in excess. Considering that such concentrations are typical for physiological conditions, this fact can be significant in identifying the mechanism of the biological action of Ge-132 and its interference with the biological catechols.

Filonova G.E. , Nikolaevskaya E.N. , Kansuzyan A.V. , Krylova I.V. , Egorov M.P. , Jouikov V.V. , Syroeshkin M.A.
Antioxidant Properties of Adrenaline in the Presence of Ge‐132
European Journal of Organic Chemistry. 2019. V.2019. N26. P.4128-4132. DOI: 10.1002/ejoc.201900331 WOS Scopus OpenAlex

Web of science:	WOS:000475679400005
Scopus:	2-s2.0-85067400402
OpenAlex:	W2945313715

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OpenAlex	8
Scopus	9
Web of science	9