Peroxy steroids derived from plant and fungi and their biological activities

Peroxy steroids derived from plant and fungi and their biological activities Review

Journal

Applied Microbiology and Biotechnology
ISSN: 1432-0614 , E-ISSN: 0175-7598

Output data

Year: 2018, Volume: 102, Number: 18, Pages: 7657-7667 Pages count : 11 DOI: 10.1007/s00253-018-9211-2

Authors

Vil Vera A ¹ , Gloriozova Tatyana A ² , Poroikov Vladimir V ² , Terent'ev Alexander O ¹ , Savidov Nick ³ , Dembitsky Valery M ^4,3

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	Institute of Biomedical Chemistry, Moscow, Russia
3	Centre for Applied Research and Innovation, Lethbridge College, Lethbridge, Canada
4	Biochemistry Lab, National Scientific Center of Marine Biology, Vladivostok, Russia

Peroxides represent a large and interesting group of biologically active natural compounds. All these metabolites contain a peroxide group (R-O-O-R). This review describes studies of more than 60 peroxides isolated from plants and fungi. Most of the plant peroxy steroids exhibit high antiprotozoal (Plasmodium) activity with a confidence of up to 95%, while steroids harvested from fungi show more antineoplastic activity with a confidence of up to 94%. In addition, more than 20 different activities of both groups of peroxides with a probability of 78 to 90% have also been predicted using computer program PASS.

Vil V.A. , Gloriozova T.A. , Poroikov V.V. , Terent'ev A.O. , Savidov N. , Dembitsky V.M.
Peroxy steroids derived from plant and fungi and their biological activities
Applied Microbiology and Biotechnology. 2018. V.102. N18. P.7657-7667. DOI: 10.1007/s00253-018-9211-2 WOS Scopus OpenAlex

≡ Web of science:	WOS:000442570500001
≡ Scopus:	2-s2.0-85049684286
≡ OpenAlex:	W2877734732