Synthesis of disaccharides for the study of human blood antibodies capable of recognizing the inner Glcβ1-3GalNAc disaccharide fragment of bacterial polysaccharides

Synthesis of disaccharides for the study of human blood antibodies capable of recognizing the inner Glcβ1-3GalNAc disaccharide fragment of bacterial polysaccharides Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2023, Volume: 33, Number: 4, Pages: 476-478 Pages count : 3 DOI: 10.1016/j.mencom.2023.06.011

Authors

Pazynina Galina V. ¹ , Tsygankova Svetlana V. ¹ , Obukhova Polina S. ^1,2 , Shilova Nadezhda V. ^1,2 , Paramonov Alexander S. ¹ , Chizhov Alexander O. ³ , Knirel Yuriy A. ³ , Bovin Nicolai V. ¹

Affiliations

1	M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation
2	National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov, 117997 Moscow, Russian Federation
3	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Disaccharides with the terminal Glcβ1-3 motif were synthesized as probes for studying human blood antibodies. An antibody isolated using Glcβ1-3GalNAcα–Sepharose was found to bind the inner part of the polysaccharide [–4GlcA6LThr3Acβ1-6Galβ1-6Glcβ1-3GalNAc6Acβ1–]n as evidenced by the use of a printed glycan array and inhibition assays.

Pazynina G.V. , Tsygankova S.V. , Obukhova P.S. , Shilova N.V. , Paramonov A.S. , Chizhov A.O. , Knirel Y.A. , Bovin N.V.
Synthesis of disaccharides for the study of human blood antibodies capable of recognizing the inner Glcβ1-3GalNAc disaccharide fragment of bacterial polysaccharides
Mendeleev Communications. 2023. V.33. N4. P.476-478. DOI: 10.1016/j.mencom.2023.06.011 WOS Scopus OpenAlex

Web of science:	WOS:001043909300001
Scopus:	2-s2.0-85166556673
OpenAlex:	W4384501528

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