PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold

PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2018, Volume: 28, Number: 4, Pages: 372-374 Pages count : 3 DOI: 10.1016/j.mencom.2018.07.010

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Anisina Yuliya E. ¹ , Goloveshkin Alexander S. ² , Ushakov Ivan E. ² , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russian Federation

The new multicomponent reaction comprises the triethylamine catalyzed assembling of salicylaldehydes, 2-aminoprop- 1-ene-1,1,3-tricarbonitrile and 3-methyl-2-pyrazolin-5-one in small amount of propanol, which affords substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 63–98% yields. This process is in agreement with PASE principles and opens the way to new chromeno[2,3-b]pyridine scaffold containing 3-methyl-2-pyrazolin-5-one fragment, which is promising for various biomedical applications.

Elinson M.N. , Vereshchagin A.N. , Anisina Y.E. , Goloveshkin A.S. , Ushakov I.E. , Egorov M.P.
PASE facile and efficient multicomponent approach to the new type of 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold
Mendeleev Communications. 2018. V.28. N4. P.372-374. DOI: 10.1016/j.mencom.2018.07.010 WOS Scopus OpenAlex

Web of science:	WOS:000442709700010
Scopus:	2-s2.0-85051013480
OpenAlex:	W2886171601

DB	Citing
OpenAlex	18
Scopus	18