Asymmetric Michael reaction between aldehydes and nitroalkanes promoted by pyrrolidine-containing C2-symmetric organocatalysts

Asymmetric Michael reaction between aldehydes and nitroalkanes promoted by pyrrolidine-containing C2-symmetric organocatalysts Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2019, Volume: 68, Number: 7, Pages: 1402-1406 Pages count : 5 DOI: 10.1007/s11172-019-2568-2

Authors

Bykova K.A. ^1,2 , Kostenko A.A. ¹ , Kucherenko A.S. ¹ , Zlotin S.G. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	Dmitry Mendeleev University of Chemical Technology of Russia, 9 Miusskaya pl., 125047 Moscow, Russian Federation

Bifunctional C2-symmetric organocatalysts derived from chiral 1,2-diaminoethanes and (S)-2-aminomethylpyrrolidine were fi rst used for promoting the asymmetric Michael addition of aliphatic aldehydes to nitroalkenes. The synthesized enantioenriched (up to 82% ee) products can be transformed into various biologically active γ-aminobutyric acid derivatives.

Bykova K.A. , Kostenko A.A. , Kucherenko A.S. , Zlotin S.G.
Asymmetric Michael reaction between aldehydes and nitroalkanes promoted by pyrrolidine-containing C2-symmetric organocatalysts
Russian Chemical Bulletin. 2019. V.68. N7. P.1402-1406. DOI: 10.1007/s11172-019-2568-2 WOS OpenAlex

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