New hybrid furoxan structures with antiaggregant activity

New hybrid furoxan structures with antiaggregant activity Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2018, Volume: 28, Number: 6, Pages: 595-597 Pages count : 3 DOI: 10.1016/j.mencom.2018.11.010

Authors

Larin Alexander A. ¹ , Fershtat Leonid L. ¹ , Ustyuzhanina Nadezhda E. ¹ , Gening Marina L. ¹ , Nifantiev Nikolay E. ¹ , Makhova Nina N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

A series of functionalized furoxans was synthesized, and their effect on the platelet aggregation was estimated using a set of inducers. New hybrid structures comprising the furoxan ring and glycolic or acetylsalicylic acid motifs effectively inhibit aggregate formation induced by adenosine diphosphate and adrenaline. Studies of their NO-donor ability showed that their antiplatelet effects were mainly independent of the NO action.

Larin A.A. , Fershtat L.L. , Ustyuzhanina N.E. , Gening M.L. , Nifantiev N.E. , Makhova N.N.
New hybrid furoxan structures with antiaggregant activity
Mendeleev Communications. 2018. V.28. N6. P.595-597. DOI: 10.1016/j.mencom.2018.11.010 WOS Scopus OpenAlex

Web of science:	WOS:000455070900010
Scopus:	2-s2.0-85057593370
OpenAlex:	W2904727335

DB	Citing
OpenAlex	21
Scopus	21
Web of science	21