Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity

Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2018, Volume: 67, Number: 5, Pages: 858-865 Pages count : 8 DOI: 10.1007/s11172-018-2150-3

Authors

Samet A.V. ¹ , Sil’yanova E.A. ^1,2 , Ushkarov V.I. ¹ , Semenova M.N. ³ , Semenov V.V. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow (Russian Federation)
2	D. I. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
3	N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russian Federation

The Barton–Zard reaction of nitro substituted stilbenes and chalcones with ethyl isocyanoacetate afforded 3,4-diaryl- and 4-acyl-3-arylpyrroles, respectively. 3-Arylpyrrole-2,4- dicarboxylates and 4-arylisoxazoline N-oxides were side reaction products. Antimitotic activity of target 3,4-disubstituted pyrroles was studied on a sea urchin embryo model. Pyrroles unsubstituted at positions 2 and 5 were the most active. The activity increased with the number of methoxy groups in the Ar substituent.

Samet A.V. , Sil’yanova E.A. , Ushkarov V.I. , Semenova M.N. , Semenov V.V.
Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity
Russian Chemical Bulletin. 2018. V.67. N5. P.858-865. DOI: 10.1007/s11172-018-2150-3 WOS Scopus OpenAlex

Web of science:	WOS:000442228300014
Scopus:	2-s2.0-85051840133
OpenAlex:	W2888064705

DB	Citing
OpenAlex	13
Scopus	12
Web of science	13