Synthesis of aurone derivatives on the basis of 2,4,6-trihydroxytoluene

Synthesis of aurone derivatives on the basis of 2,4,6-trihydroxytoluene Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2019, Volume: 55, Number: 12, Pages: 1174-1178 Pages count : 5 DOI: 10.1007/s10593-019-02597-0

Authors

Shubin Dmitry A. ¹ , Kuznetsov Dmitry N. ¹ , Kobrakov Konstantin I. ¹ , Starosotnikov Alexey M. ² , Merkulova Natal’ya L. ²

Affiliations

1	Russian State University named after A. N. Kosygin (Technology. Design. Art), 1 Malaya Kaluzhskaya St., Moscow 119991, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

2,4,6-Trihydroxytoluene (2-methylphloroglucinol) was used as starting material for the first synthesis of several (Z)-2-arylidene-4,6-dihydroxy-7-methylaurones, including a synthetic analog of the natural 7-methylaureusidin, which is currently obtained mainly from the extract of sedge capitata (Cyperus capitatus). It was shown that the reaction of 2,4,6-trihydroxytoluene with chloroacetonitrile occurred regioselectively, with the formation of 4,6-dihydroxy-7-methylbenzofuran-3(2H)-one, the treatment of which with substituted benzaldehydes gave high yields of the target compounds.

Shubin D.A. , Kuznetsov D.N. , Kobrakov K.I. , Starosotnikov A.M. , Merkulova N.L.
Synthesis of aurone derivatives on the basis of 2,4,6-trihydroxytoluene
Chemistry of Heterocyclic Compounds. 2019. V.55. N12. P.1174-1178. DOI: 10.1007/s10593-019-02597-0 WOS Scopus OpenAlex

Web of science:	WOS:000504155300002
Scopus:	2-s2.0-85077164726
OpenAlex:	W2996491544

DB	Citing
OpenAlex	6
Scopus	5
Web of science	4