Synthesis of gem-Difluorinated Hydroxypyrrolidines

Synthesis of gem-Difluorinated Hydroxypyrrolidines Full article

Journal

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Output data

Year: 2017, Volume: 82, Number: 6, Pages: 3270-3275 Pages count : 6 DOI: 10.1021/acs.joc.6b03033

Authors

Fedorov Oleg V. ¹ , Struchkova Marina I. ¹ , Dilman Alexander D. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation

A method for the synthesis of 3-hydroxy-4,4-difluoropyrrolidines from α,α-difluoro-β-bromoketones is described. The reaction involves methylenation of the carbonyl group with tetrahydrothiophenium ylide followed by coupling with primary amines.

Fedorov O.V. , Struchkova M.I. , Dilman A.D.
Synthesis of gem-Difluorinated Hydroxypyrrolidines
Journal of Organic Chemistry. 2017. V.82. N6. P.3270-3275. DOI: 10.1021/acs.joc.6b03033 WOS Scopus OpenAlex

Web of science:	WOS:000397077500046
Scopus:	2-s2.0-85015677962
OpenAlex:	W2589977373

DB	Citing
OpenAlex	9
Scopus	8
Web of science	8