The O-polysaccharide of Escherichia coli F5, which is structurally related to that of E. coli O28ab, provides cells only weak protection against bacteriophage attack

The O-polysaccharide of Escherichia coli F5, which is structurally related to that of E. coli O28ab, provides cells only weak protection against bacteriophage attack Full article

Journal

Archives of Virology
ISSN: 0304-8608 , E-ISSN: 1432-8798

Output data

Year: 2019, Volume: 164, Number: 11, Pages: 2783-2787 Pages count : 5 DOI: 10.1007/s00705-019-04371-1

Authors

Golomidova A.K. ¹ , Naumenko O.I. ² , Senchenkova S.N. ² , Knirel Y.A. ^1,2 , Letarov A.V. ^1,3

Affiliations

1	S. N. Winogradsky Institute of Microbiology, Federal Research Centre, “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
3	Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russian Federation

Several types of Escherichia coli O-antigens form highly effective shields protecting the bacterial cell surface and preventing bacteriophages from interacting directly with their secondary (terminal) receptors. However, it is not clear if O-antigens of various types (O-serotypes) differ in their anti-phage protection efficacy. Here, we describe a new E. coli strain, F5, which has an E. coli O28ab-related O-antigen. Although the amount of O-antigen produced by this strain is comparable to that produced by other E. coli strains we tested, it appears to give the cells significantly lower protection against phage attack than other O-antigen types, such as the O-polysaccharide of E. coli F17, which we studied earlier.

Golomidova A.K. , Naumenko O.I. , Senchenkova S.N. , Knirel Y.A. , Letarov A.V.
The O-polysaccharide of Escherichia coli F5, which is structurally related to that of E. coli O28ab, provides cells only weak protection against bacteriophage attack
Archives of Virology. 2019. V.164. N11. P.2783-2787. DOI: 10.1007/s00705-019-04371-1 WOS Scopus OpenAlex

Web of science:	WOS:000488510500015
Scopus:	2-s2.0-85070714430
OpenAlex:	W2968939014

DB	Citing
OpenAlex	10
Scopus	7
Web of science	7