Nitrobenzofuroxane derivatives as dual action HIV-1 inhibitors

Nitrobenzofuroxane derivatives as dual action HIV-1 inhibitors Full article

Journal

Biochemistry (Moscow). Supplement Series B: Biomedical Chemistry
ISSN: 1990-7508 , E-ISSN: 1990-7516

Output data

Year: 2017, Volume: 11, Number: 3, Pages: 286-290 Pages count : 5 DOI: 10.1134/s1990750817030064

Authors

Korolev S.P. ¹ , Pustovarova M.A. ¹ , Starosotnikov A.M. ² , Bastrakov M.A. ² , Agapkina Yu.Yu. ¹ , Shevelev S.A. ² , Gottikh M.B. ¹

Affiliations

1	Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia
2	Zelinsky Institute of Organic Chemistry, Moscow, Russia

Human immunodeficiency virus type 1 (HIV-1) causes one of the most dangerous diseases, HIV infection and AIDS. The search for new inhibitors of the virus still remains an urgent task. One of approaches to suppress the HIV infection is the use of dual action HIV-1 inhibitors, i.e. inhibitors targeting two stages of the viral life cycle. The catalytic domain of HIV-1 integrase shares similar structural organization with the ribonuclease (RNase H) domain of HIV-1 reverse transcriptase, and therefore an approach aimed at creation of dual action inhibitors which would simultaneously inhibit HIV-1 integrase and RNase H seems to be very promising. In this work we have synthesized a series of 6-nitrobenzofuroxane derivatives and studied their inhibitory activity towards two HIV-1 enzymes, integrase and RNase H.

Korolev S.P. , Pustovarova M.A. , Starosotnikov A.M. , Bastrakov M.A. , Agapkina Y.Y. , Shevelev S.A. , Gottikh M.B.
Nitrobenzofuroxane derivatives as dual action HIV-1 inhibitors
Biochemistry (Moscow). Supplement Series B: Biomedical Chemistry. 2017. V.11. N3. P.286-290. DOI: 10.1134/s1990750817030064 WOS Scopus OpenAlex

Web of science:	WOS:000417442000009
Scopus:	2-s2.0-85027863302
OpenAlex:	W4251403457

DB	Citing
OpenAlex	9
Scopus	9
Web of science	9