Structure of the K82 Capsular Polysaccharide from Acinetobacter baumannii LUH5534 Containing a d-Galactose 4,6-Pyruvic Acid Acetal

Structure of the K82 Capsular Polysaccharide from Acinetobacter baumannii LUH5534 Containing a d-Galactose 4,6-Pyruvic Acid Acetal Full article

Journal

Biokhimiya
ISSN: 0006-2979 , E-ISSN: 1608-3040

Output data

Year: 2018, Volume: 83, Number: 7, Pages: 831-835 Pages count : 5 DOI: 10.1134/s0006297918070064

Authors

Kasimova Anastasiya ^1,2 , Kenyon Johanna ^3,4 , Arbatsky Nikolay ¹ , Shashkov Alexander ¹ , Popova Anastasiya ^5,6 , Knirel Yuriy ¹ , Hall Ruth ⁴

Affiliations

1	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	Higher Chemical College of the Russian Academy of Sciences, D. I. Mendeleev University of Chemical Technology of Russia, Moscow, Russia
3	Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia
4	School of Molecular Bioscience, The University of Sydney, Sydney, Australia
5	Moscow Institute of Physics and Technology, Dolgoprudny, Russia
6	State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia

Type K82 capsular polysaccharide (CPS) was isolated from Acinetobacter baumannii LUH5534. The structure of a linear tetrasaccharide repeating unit of the CPS was established by sugar analysis along with one- and two-dimensional 1H and 13C NMR spectroscopy. Proteins encoded by the KL82 capsule gene cluster in the genome of LUH5534 were assigned to roles in the synthesis of the K82 CPS. In particular, functions were assigned to two new glycosyltransferases (Gtr152 and Gtr153) and a novel pyruvyltransferase, Ptr5, responsible for the synthesis of D-galactose 4,6-(R)-pyruvic acid acetal.

Kasimova A. , Kenyon J. , Arbatsky N. , Shashkov A. , Popova A. , Knirel Y. , Hall R.
Structure of the K82 Capsular Polysaccharide from Acinetobacter baumannii LUH5534 Containing a d-Galactose 4,6-Pyruvic Acid Acetal
Biokhimiya. 2018. V.83. N7. P.831-835. DOI: 10.1134/s0006297918070064 WOS Scopus OpenAlex

Web of science:	WOS:000438820800006
Scopus:	2-s2.0-85050249541
OpenAlex:	W2883469316

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