Green asymmetric synthesis of tetrahydroquinolines in carbon dioxide medium promoted by lipophilic bifunctional tertiary amine – squaramide organocatalysts Научная публикация
| Журнал |
Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416 |
||
|---|---|---|---|
| Вых. Данные | Год: 2018, Том: 74, Номер: 1, Страницы: 157-164 Страниц : 8 DOI: 10.1016/j.tet.2017.11.057 | ||
| Авторы |
|
||
| Организации |
|
Реферат:
Novel pseudo-enantiomeric bifunctional tertiary amine-squaramides modified with long-chained alkoxy or polyfluoroalkoxy groups, have been synthesized. They catalyzed the asymmetric double-Michael cascade reactions of o-N-tosylaminophenyl α,β-unsaturated ketones with α-nitroolefins in carbon dioxide medium at significantly lower pressure (75 bar) and temperature (35 °C), than known less lipophilic catalysts. Both enantiomers of the pharmacologically valuable methoxy-substituted tetrahydroquinoline derivatives can be prepared in moderate to high yield with promising enantioselectivity (up to 98% ee) under the optimized conditions.
Библиографическая ссылка:
Filatova E.V.
, Turova O.V.
, Nigmatov A.G.
, Zlotin S.G.
Green asymmetric synthesis of tetrahydroquinolines in carbon dioxide medium promoted by lipophilic bifunctional tertiary amine – squaramide organocatalysts
Tetrahedron. 2018. V.74. N1. P.157-164. DOI: 10.1016/j.tet.2017.11.057 WOS Scopus OpenAlex
Green asymmetric synthesis of tetrahydroquinolines in carbon dioxide medium promoted by lipophilic bifunctional tertiary amine – squaramide organocatalysts
Tetrahedron. 2018. V.74. N1. P.157-164. DOI: 10.1016/j.tet.2017.11.057 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000418728200021 |
| Scopus: | 2-s2.0-85036641050 |
| OpenAlex: | W2769688439 |