Synthesis and cytotoxic activities of difluoroacetyl-substituted hexahydropyrimidine derivatives

Synthesis and cytotoxic activities of difluoroacetyl-substituted hexahydropyrimidine derivatives Научная публикация

Журнал

Journal of Fluorine Chemistry
ISSN: 1873-3328 , E-ISSN: 0022-1139

Вых. Данные

Год: 2018, Том: 211, Страницы: 94-99 Страниц : 6 DOI: 10.1016/j.jfluchem.2018.04.011

Авторы

Gibadullina Natalya N. ¹ , Latypova Dilara R. ¹ , Vakhitov Vener A. ² , Khasanova Diana V. ² , Zainullina Liana F. ^2,3 , Vakhitova Yulia V. ^2,3 , Lobov Aleksandr N. ¹ , Ugrak Bogdan I. ⁴ , Tomilov Yury V. ⁴ , Dokichev Vladimir A. ¹

Организации

1	Ufa Institute of Chemistry – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 prospect Oktyabrya, 450054, Ufa, Russian Federation
2	Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, 71 prospect Oktyabrya, 450054, Ufa, Russian Federation
3	State Zakusov Institute of Pharmacology, 8 Baltiyskaya Street, 125315, Moscow, Russian Federation
4	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation

A series of novel difluoroacetyl hexahydropyrimidine derivatives have been synthesized by reactions of ethyl 4,4-difluoroacetoacetate, 1,1-difluoropentane-2,4-dione and 1,1,5,5-tetrafluoropentane-2,4-dione with an aqueous formaldehyde solution and amino acid ester hydrochlorides under Mannich reaction conditions. The in vitro cytotoxic activity of fluorine-containing hexahydropyrimidine derivatives were determined in cancer (Jurkat and HepG2) and conditionally normal (HEK293) human cells.

Gibadullina N.N. , Latypova D.R. , Vakhitov V.A. , Khasanova D.V. , Zainullina L.F. , Vakhitova Y.V. , Lobov A.N. , Ugrak B.I. , Tomilov Y.V. , Dokichev V.A.
Synthesis and cytotoxic activities of difluoroacetyl-substituted hexahydropyrimidine derivatives
Journal of Fluorine Chemistry. 2018. V.211. P.94-99. DOI: 10.1016/j.jfluchem.2018.04.011 WOS Scopus OpenAlex

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