Asymmetric synthesis of warfarin and its analogs catalyzed by C2-symmetric squaramide-based primary diamines Научная публикация
| Журнал |
Organic & Biomolecular Chemistry
ISSN: 1477-0520 , E-ISSN: 1477-0539 |
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| Вых. Данные | Год: 2018, Том: 16, Номер: 35, Страницы: 6423-6429 Страниц : 7 DOI: 10.1039/c8ob01576g | ||
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Реферат:
Novel C2-symmetric N,N′-bis(2-amino-1,2-diphenylethyl)squaramides with 1,2-di(pyridin-2-yl)ethane and 1,2-diphenylethane spacer groups were designed and applied as organocatalysts in asymmetric additions of 4-hydroxycoumarin and 4-hydroxy-6-methyl-2H-pyran-2-one to α,β-unsaturated ketones. Both enantiomers of the anticoagulant warfarin and its analogs were prepared in up to 96% yield and with 96% ee. Recyclability of the developed catalysts and synthetic utility of the prepared Michael adducts for asymmetric synthesis of potential chiral medications via acylation reactions were demonstrated.
Библиографическая ссылка:
Kochetkov S.V.
, Kucherenko A.
, Zlotin S.G.
Asymmetric synthesis of warfarin and its analogs catalyzed by C2-symmetric squaramide-based primary diamines
Organic & Biomolecular Chemistry. 2018. V.16. N35. P.6423-6429. DOI: 10.1039/c8ob01576g WOS Scopus OpenAlex
Asymmetric synthesis of warfarin and its analogs catalyzed by C2-symmetric squaramide-based primary diamines
Organic & Biomolecular Chemistry. 2018. V.16. N35. P.6423-6429. DOI: 10.1039/c8ob01576g WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000444484800007 |
| Scopus: | 2-s2.0-85053526611 |
| OpenAlex: | W2883059706 |