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Mesoporous particle-based microcontainers for intranasal delivery of imidazopyridine drugs Full article

Journal Journal of Microencapsulation
ISSN: 1464-5246 , E-ISSN: 0265-2048
Output data Year: 2018, Volume: 35, Number: 7-8, Pages: 657-666 Pages count : 10 DOI: 10.1080/02652048.2019.1571642
Authors Marchenko Irina 1,2 , Borodina Tatiana 3,2 , Trushina Daria 4,2 , Rassokhina Irina 5 , Volkova Yulia 5 , Shirinian Valerii 5 , Zavarzin Igor 5 , Gogin Andrey 1 , Bukreeva Tatiana 1,2
Affiliations
1 National Research Centre “Kurchatov Institute”, Moscow, Russia;
2 Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences, Moscow, Russia;
3 Institute of Molecular Medicine Sechenov First Moscow State Medical University, Moscow, Russia;
4 Institute of Molecular Medicine Sechenov First Moscow State Medical University, Moscow, Russia
5 N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Moscow, Russia

Abstract: The aim of this study was to develop mesoporous containers for entrapment of imidazopyridines, such as sedative–hypnotic medicine zolpidem, anxiolytic agent alpidem and their derivatives. For this purpose, calcium carbonate (size 1.2 µm (PDI: 0.6), zeta potential: −10 mV), manganese carbonate (2.5 µm (PDI: 0.5), zeta potential: −12 mV) and titanium dioxide particles (3.7 µm (PDI: 0.4), zeta potential: −15 mV) were used. The compounds were encapsulated applying two techniques: adsorption on the preformed particles and co-precipitation during the synthesis of the particles. The polymer shell of the containers was formed by electrostatic adsorption of polyelectrolytes on the surface of the particles. The best encapsulation efficacy was shown for zolpidem incorporated into calcium carbonate (5.4%) and manganese carbonate (4.6%) by adsorption. Release of the compounds from the containers based on the proposed particles were characterised by the short time burst effect (<10 min) followed by desorption prolongation by formation of polymer shell. X-ray microtomography results demonstrate the prolonged retention of the containers with the mucoadhesive shell in the nasal cavity.
Cite: Marchenko I. , Borodina T. , Trushina D. , Rassokhina I. , Volkova Y. , Shirinian V. , Zavarzin I. , Gogin A. , Bukreeva T.
Mesoporous particle-based microcontainers for intranasal delivery of imidazopyridine drugs
Journal of Microencapsulation. 2018. V.35. N7-8. P.657-666. DOI: 10.1080/02652048.2019.1571642 WOS Scopus OpenAlex
Identifiers:
Web of science: WOS:000461484500004
Scopus: 2-s2.0-85061029142
OpenAlex: W2912744426
Citing:
DB Citing
OpenAlex 18
Scopus 16
Web of science 16
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