Reductive Amidation without an External Hydrogen Source Using Rhodium on Carbon Matrix as a Catalyst

Reductive Amidation without an External Hydrogen Source Using Rhodium on Carbon Matrix as a Catalyst Full article

Journal

ChemCatChem
ISSN: 1867-3899 , E-ISSN: 1867-3880

Output data

Year: 2020, Volume: 12, Number: 1, Pages: 112-117 Pages count : 6 DOI: 10.1002/cctc.201901465

Authors

Tsygankov Alexey A. ¹ , Makarova Maria ^1,2 , Afanasyev Oleg I. ¹ , Kashin Alexey S. ³ , Naumkin Alexander V. ^1,4 , Loginov Dmitry A. ¹ , Chusov Denis ^1,5

Affiliations

1	A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, 28 Vavilova str., Moscow, 119991 Russia
2	Higher Chemical College, Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow, 125047 Russia
3	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47, Moscow, 119991 Russia
4	Moscow Institute of Physics and Technology, State University, Institutskiy Pereulok 9, Dolgoprudny, 141701 Russia
5	G.V. Plekhanov Russian University of Economics, 36 Stremyanny Per., Moscow, 117997 Russia

An efficient method for preparation of secondary amides from primary amides and aldehydes using rhodium on carbon matrix as catalyst was developed. The method does not require any external hydrogen source and carbon monoxide is used as a reducing agent. The most active rhodium catalysts were characterized by BET, TEM and XPS techniques. Unexpectedly, it was found that heterogeneous rhodium on carbon matrix works as precatalyst for homogenous active species due to leaching of rhodium to the solution. Various secondary amides were synthesized and checked for antifungal activity. 4-Methoxy-N-(4-methoxybenzyl)benzamide demonstrated promising activity against Rhizoctonia Solani.

Tsygankov A.A. , Makarova M. , Afanasyev O.I. , Kashin A.S. , Naumkin A.V. , Loginov D.A. , Chusov D.
Reductive Amidation without an External Hydrogen Source Using Rhodium on Carbon Matrix as a Catalyst
ChemCatChem. 2020. V.12. N1. P.112-117. DOI: 10.1002/cctc.201901465 WOS Scopus OpenAlex

≡ Web of science:	WOS:000497786700001
≡ Scopus:	2-s2.0-85075486882
≡ OpenAlex:	W2979196813