Driving Force of the Pyranoside-into-Furanoside Rearrangement

Driving Force of the Pyranoside-into-Furanoside Rearrangement Full article

Journal

ACS Omega
ISSN: 2470-1343

Output data

Year: 2019, Volume: 4, Number: 1, Pages: 1139-1143 Pages count : 5 DOI: 10.1021/acsomega.8b03274

Authors

Gerbst Alexey G. ¹ , Krylov Vadim B. ¹ , Argunov Dmitry A. ¹ , Dmitrenok Andrey S. ¹ , Nifantiev Nikolay E. ¹

Affiliations

1	Laboratory of Glycoconjugate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia

Ab initio calculations of fully O-sulfated model monosaccharides, including common hexoses (glucose, galactose, fucose, and mannose) and pentoses (arabinose and xylose), were performed to study the energetic properties of the recently discovered pyranoside-into-furanoside (PIF) rearrangement. It was shown that the per-O-sulfated derivatives of furanoside isomers generally had lower energies than the corresponding per-O-sulfated pyranosides, while nonsulfated furanosides were always less favored than nonsulfated pyranosides. Mannose, which is known to be unreactive in PIF rearrangement, was the only exception. The results of the theoretical calculations were confirmed by experimental studies of monosaccharide models and explained the driving force of such unusual ring contraction process as PIF rearrangement. The conclusions of performed investigation can be used for prediction of new substrates applicability for PIF rearrangement.

Gerbst A.G. , Krylov V.B. , Argunov D.A. , Dmitrenok A.S. , Nifantiev N.E.
Driving Force of the Pyranoside-into-Furanoside Rearrangement
ACS Omega. 2019. V.4. N1. P.1139-1143. DOI: 10.1021/acsomega.8b03274 WOS Scopus OpenAlex

≡ Web of science:	WOS:000460214700123
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