Synthesis of novel substituted (4H-furo[2,3-h]chromen-9-yl)-acetic acids via multicomponent reaction of flavones, arylglyoxals and Meldrum’s acid

Synthesis of novel substituted (4H-furo[2,3-h]chromen-9-yl)-acetic acids via multicomponent reaction of flavones, arylglyoxals and Meldrum’s acid Full article

Journal

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Output data

Year: 2021, Volume: 83, Article number : 131980, Pages count : DOI: 10.1016/j.tet.2021.131980

Authors

Lichitsky Boris V. ¹ , Melekhina Valeriya G. ¹ , Komogortsev Andrey N. ¹ , Migulin Vasily A. ¹ , Nelyubina Yulia V. ² , Fakhrutdinov Artem N. ¹ , Daeva Elena D. ¹ , Dudinov Arkady A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr., 47, Moscow, 119991, Russian Federation
2	A.N. Nesmeyanov Institute of Organoelement Compound, Russian Academy of Sciences, Vavilova St. 28, Moscow, 119991, Russian Federation

An efficient one-pot method for the synthesis of previously unknown furanoflavone derivatives was elaborated. The suggested approach based on telescoped multicomponent reaction of various flavones, arylglyoxals and Meldrum’s acid. A distinctive feature of studied condensation is regiospecific formation of 4H-furo[2,3-h]chromene core. The advantages of this synthesis are mild conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of furanoflavone derivatives was determined by X-ray diffraction.

Lichitsky B.V. , Melekhina V.G. , Komogortsev A.N. , Migulin V.A. , Nelyubina Y.V. , Fakhrutdinov A.N. , Daeva E.D. , Dudinov A.A.
Synthesis of novel substituted (4H-furo[2,3-h]chromen-9-yl)-acetic acids via multicomponent reaction of flavones, arylglyoxals and Meldrum’s acid
Tetrahedron. 2021. V.83. 131980 . DOI: 10.1016/j.tet.2021.131980 WOS Scopus OpenAlex

Web of science:	WOS:000629261100017
Scopus:	2-s2.0-85100623302
OpenAlex:	W3127060405

DB	Citing
OpenAlex	16
Scopus	16
Web of science	12