Some Transformations of 2-(Chloromethyl)-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4(3H)-one Full article
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Russian Journal of Organic Chemistry
ISSN: 1608-3393 , E-ISSN: 1070-4280 |
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| Output data | Year: 2018, Volume: 54, Number: 4, Pages: 606-613 Pages count : 8 DOI: 10.1134/s1070428018040152 | ||||
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Abstract:
The condensation of 1-amino-3,3-dimethyl-3,4-dihydronaphthalene-2-carbonitrile with chloroacetyl chloride afforded chloro-N-(2-cyano-3,3-dimethyl-3,4-dihydronaphthalen-1-yl)acetamide which underwent cyclization to 2-(chloromethyl)-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4(3H)-one. The latter reacted with various nucleophiles (alkali metal alkoxides, piperazine, 2-sulfanylethanol) to give 2-(alkoxymethyl)-, 2-(piperazin-1-ylmethyl)-, and 2-{[(2-hydroxyethyl)sulfanyl]methyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin- 4(3H)-ones. The condensation of 2-(chloromethyl)benzo[h]quinazoline with 2-thioxo derivatives of quinazoline and benzo[h]quinazolines led to the formation of bis-quinazolines in which 5,5-dimethyl-5,6- dihydrobenzo[h]quinazolin-4(3H)-one fragment is linked to quinazoline or benzo[h]quinazoline system through a CH2S bridge.
Cite:
Markosyan A.I.
, Hayrapetyan K.K.
, Gabrielyan S.H.
, Shirinyan V.Z.
, Mamyan S.S.
, Avakimyan J.A.
, Stepanyan G.M.
Some Transformations of 2-(Chloromethyl)-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4(3H)-one
Russian Journal of Organic Chemistry. 2018. V.54. N4. P.606-613. DOI: 10.1134/s1070428018040152 WOS Scopus OpenAlex
Some Transformations of 2-(Chloromethyl)-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4(3H)-one
Russian Journal of Organic Chemistry. 2018. V.54. N4. P.606-613. DOI: 10.1134/s1070428018040152 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000434488900015 |
| Scopus: | 2-s2.0-85048146285 |
| OpenAlex: | W2806437299 |