A facile and efficient multicomponent approach to 5-[5-hydroxy- 3-(trifluoromethyl)-1H-pyrazol-4-yl]-5H-chromeno[2,3-b]pyridines

A facile and efficient multicomponent approach to 5-[5-hydroxy- 3-(trifluoromethyl)-1H-pyrazol-4-yl]-5H-chromeno[2,3-b]pyridines Full article

Journal

Journal of Fluorine Chemistry
ISSN: 1873-3328 , E-ISSN: 0022-1139

Output data

Year: 2018, Volume: 213, Pages: 31-36 Pages count : 6 DOI: 10.1016/j.jfluchem.2018.06.008

Authors

Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Anisina Yuliya E. ¹ , Fakhrutdinov Artem N. ¹ , Goloveshkin Alexander S. ² , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991, Moscow, Russian Federation
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Vavilova 28, 119991, Moscow, Russian Federation

The new multicomponent reaction has been found: the pyridine or triethylamine catalyzed multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 3-trifluoromethyl-2-pyrazolin-5-one results in efficient formation of the earlier unknown substituted 2,4-diamino-5-[5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 58–92% yields. This new process opens a facile and efficient way to the new type of functionalized 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold, containing the 3-trifluoromethyl-2-pyrazolin-5-one fragment, which are promising compounds for different biomedical applications.

Elinson M.N. , Vereshchagin A.N. , Anisina Y.E. , Fakhrutdinov A.N. , Goloveshkin A.S. , Egorov M.P.
A facile and efficient multicomponent approach to 5-[5-hydroxy- 3-(trifluoromethyl)-1H-pyrazol-4-yl]-5H-chromeno[2,3-b]pyridines
Journal of Fluorine Chemistry. 2018. V.213. P.31-36. DOI: 10.1016/j.jfluchem.2018.06.008 WOS Scopus OpenAlex

Web of science:	WOS:000442710700005
Scopus:	2-s2.0-85049422626
OpenAlex:	W2809990169

DB	Citing
OpenAlex	12
Scopus	13
Web of science	13