Multicomponent synthesis of 1,4-dihydropyridine-3,5-dicarbonitriles

Multicomponent synthesis of 1,4-dihydropyridine-3,5-dicarbonitriles Full article

Journal

Arkivoc
ISSN: 1551-7012 , E-ISSN: 1551-7004

Output data

Year: 2022, Number: 5, Pages: 126-134 Pages count : 9 DOI: 10.24820/ark.5550190.p011.703

Authors

Ryzhkova Yuliya E. ¹ , Elinson Michail N. ¹

Affiliations

1	Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

1,4-Dihydropyridines are one of the most used classes of antihypertensive drugs. The present communication describes the autocatalytic four-component reaction of 2,6-dihalogen-substituted benzaldehydes, malononitrile and cyclic amines results in the formation of previously unknown 1,4-dihydropyridine-3,5- dicarbonitriles. The structure of these previously unknown compounds was confirmed by means of 1H and 13C NMR and IR spectroscopy, mass spectrometry and elemental analysis.

Ryzhkova Y.E. , Elinson M.N.
Multicomponent synthesis of 1,4-dihydropyridine-3,5-dicarbonitriles
Arkivoc. 2022. N5. P.126-134. DOI: 10.24820/ark.5550190.p011.703 WOS Scopus OpenAlex

≡ Web of science:	WOS:000811734900012
≡ Scopus:	2-s2.0-85131236491
≡ OpenAlex:	W4221008820