Simple approach towards phosphorus-substituted spiro 1,3,4-thiadiazolines | Sciact

Simple approach towards phosphorus-substituted spiro 1,3,4-thiadiazolines Научная публикация

Журнал

Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416

Вых. Данные

Год: 2024, Том: 150, Номер статьи : 133746, Страниц : DOI: 10.1016/j.tet.2023.133746

Авторы

Kozlov Mikhail ¹ , Tyurin Alexey ¹ , Dmitrenok Andrey ¹ , Rusak Vyacheslav ¹ , Fedorov Aleksander ¹ , Zavarzin Igor ¹ , Volkova Yulia ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences 47 Leninsky prosp., 119991, Moscow, Russia

This study reports the first general, practical, and facile synthesis of phosphorus-substituted 1,3,4-thiadiazolines starting from phosphorylthioformic acid hydrazides and ketones. Various cyclic ketones were efficiently incorporated into spiro 1,3,4-thiadiazoline derivatives by a two-step sequence involving the heterocyclization with phosphorylthioformic acid hydrazides followed by the nitrogen acylation with acyl chlorides. The protocol is characterized by operational simplicity, readily available reagents, and functional group tolerance.

Kozlov M. , Tyurin A. , Dmitrenok A. , Rusak V. , Fedorov A. , Zavarzin I. , Volkova Y.
Simple approach towards phosphorus-substituted spiro 1,3,4-thiadiazolines
Tetrahedron. 2024. V.150. 133746 . DOI: 10.1016/j.tet.2023.133746 WOS Scopus OpenAlex

≡ Web of science:	WOS:001125040600001
≡ Scopus:	2-s2.0-85177839987
≡ OpenAlex:	W4388672719