Boosting the generality of catalytic systems by the synergetic ligand effect in Pd-catalyzed C-N cross-coupling

Boosting the generality of catalytic systems by the synergetic ligand effect in Pd-catalyzed C-N cross-coupling Full article

Journal

Journal of Catalysis
ISSN: 0021-9517 , E-ISSN: 1090-2694

Output data

Year: 2024, Volume: 429, Article number : 115240, Pages count : DOI: 10.1016/j.jcat.2023.115240

Authors

Grebennikov Nikolay O. ^1,2 , Boiko Daniil A. ¹ , Prima Darya O. ¹ , Madiyeva Malena ¹ , Minyaev Mikhail E. ¹ , Ananikov Valentine P. ¹

Affiliations

1	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospekt 47, Moscow 119991, Russia
2	Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia

In the areas of catalysis and organic chemistry, the development of versatile and efficient catalytic systems has long been a challenge, primarily due to the intricate relationship between ligands and transition metal centers. This study addresses this challenge by exploring the concept of ligand synergy to enhance the generality of catalytic systems, a crucial metric for their practical utility. By combining N-heterocyclic carbene (NHC) and phosphine ligands, we unveil a novel catalytic system that exhibits high level of generality in the Buchwald-Hartwig cross-coupling reaction. Our findings not only demonstrate the enhanced efficiency of this system, leading to the synthesis of valuable compounds with applications in organic electroluminescent devices and the pharmaceutical industry, but also shed light on the broader potential of ligand synergy in catalysis. Through machine learning analysis, we uncover the critical role of specific ligand properties, further paving the way for rational catalyst design.

Grebennikov N.O. , Boiko D.A. , Prima D.O. , Madiyeva M. , Minyaev M.E. , Ananikov V.P.
Boosting the generality of catalytic systems by the synergetic ligand effect in Pd-catalyzed C-N cross-coupling
Journal of Catalysis. 2024. V.429. 115240 . DOI: 10.1016/j.jcat.2023.115240 WOS Scopus OpenAlex

Web of science:	WOS:001137808400001
Scopus:	2-s2.0-85179799515
OpenAlex:	W4389328979

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