Structure and genetics ofEscherichia coliO antigens

Structure and genetics ofEscherichia coliO antigens Review

Journal

FEMS Microbiology Reviews
ISSN: 1574-6976 , E-ISSN: 0168-6445

Output data

Year: 2020, Volume: 44, Number: 6, Pages: 655-683 Pages count : 29 DOI: 10.1093/femsre/fuz028

Authors

Liu Bin ^1,2,3 , Furevi Axel ⁴ , Perepelov Andrei V. ⁵ , Guo Xi ^1,2,3 , Cao Hengchun ^1,2,3 , Wang Quan ^1,2,3 , Reeves Peter R. ⁶ , Knirel Yuriy A. ⁵ , Wang Lei ^1,2,3 , Widmalm Göran ⁴

Affiliations

1	TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjing 300457, China
2	The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, 23 Hongda Street, TEDA, Tianjin 300457, China
3	Tianjin Key Laboratory of Microbial Functional Genomics, 23 Hongda Street, TEDA, Tianjin 300457, China
4	Department of Organic Chemistry, Arrhenius Laboratory, Svante Arrhenius väg 16C, Stockholm University, S-106 91 Stockholm, Sweden
5	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 47, Moscow, Russia
6	School of Molecular and Microbial Bioscience, University of Sydney, 2 Butilin Ave, Darlington NSW 2008, Sydney, Australia

Escherichia coli includes clonal groups of both commensal and pathogenic strains, with some of the latter causing serious infectious diseases. O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis for many serotyping schemes for Gram-negative bacteria. This review covers the diversity in E. coli O antigen structures and gene clusters, and the genetic basis for the structural diversity. Of the 187 formally defined O antigens, six (O31, O47, O67, O72, O94 and O122) have since been removed and three (O34, O89 and O144) strains do not produce any O antigen. Therefore, structures are presented for 176 of the 181 E. coli O antigens, some of which include subgroups. Most (93%) of these O antigens are synthesized via the Wzx/Wzy pathway, 11 via the ABC transporter pathway, with O20, O57 and O60 still uncharacterized due to failure to find their O antigen gene clusters. Biosynthetic pathways are given for 38 of the 49 sugars found in E. coli O antigens, and several pairs or groups of the E. coli antigens that have related structures show close relationships of the O antigen gene clusters within clades, thereby highlighting the genetic basis of the evolution of diversity.

Liu B. , Furevi A. , Perepelov A.V. , Guo X. , Cao H. , Wang Q. , Reeves P.R. , Knirel Y.A. , Wang L. , Widmalm G.
Structure and genetics ofEscherichia coliO antigens
FEMS Microbiology Reviews. 2020. V.44. N6. P.655-683. DOI: 10.1093/femsre/fuz028 WOS Scopus OpenAlex

Web of science:	WOS:000605984700001
Scopus:	2-s2.0-85096889480
OpenAlex:	W2990575195

DB	Citing
OpenAlex	271
Web of science	195
Scopus	218